Hormonal therapies · 2026

A multicentre randomized trial of letrozole

Randomized controlled trial

Library updated:

A multicentre randomized trial of letrozole

What was investigated and what was found?

Among 296 men, including 218 with NOA, letrozole improved the sperm concentration category.

Interpreting the findings

The study included mixed diagnoses. The primary endpoint was sperm concentration category, not pregnancy or live birth.

How can you prepare for a consultation?

Discuss hormonal-treatment publications using your existing hormone results and previous treatment history. Ask how the study diagnoses compare with your circumstances, which outcome was measured, and whether the publication reports completed research or only a protocol. Changes in sperm concentration should be considered separately from pregnancy and live-birth outcomes.

What does this research mean for your situation?

Let us begin with your diagnosis, previous findings and goals as a couple. You can request an initial consultation with Prof. Dr. Mehmet Çolakoğlu to discuss what this research means for your own situation.

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