Genetic assessment and PGT · 2025

Sperm DNA fragmentation and embryo chromosome status

Systematic review / meta-analysis · 1516 treatment cycles

Library updated:

Sperm DNA fragmentation and embryo chromosome status

What was investigated and what was found?

Across six studies, the 30% fragmentation threshold was associated with lower embryo euploidy, while the 15% threshold was not. An association does not prove that treating it improves births.

Interpreting the findings

Patient groups, methods and bias risks can differ across studies. A pooled estimate is not a personal treatment recommendation or a guarantee of benefit.

How can you prepare for a consultation?

Genetic-testing decisions depend on age, embryo numbers, family history and previous pregnancies. Bring existing reports to your initial consultation; genetic counselling can be incorporated when appropriate.

What does this research mean for your situation?

Let us begin with your diagnosis, previous findings and goals as a couple. You can request an initial consultation with Prof. Dr. Mehmet Çolakoğlu to discuss what this research means for your own situation.

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