Stimulation protocols and safety · 2026

Antagonist versus agonist protocols in normal responders

Systematic review / meta-analysis · 1841 participants

Library updated:

Antagonist versus agonist protocols in normal responders

What was investigated and what was found?

Eight trials linked antagonist protocols to shorter stimulation, less medication and lower OHSS risk. Egg yield was slightly lower, while clinical pregnancy did not differ significantly.

Interpreting the findings

Patient groups, methods and bias risks can differ across studies. A pooled estimate is not a personal treatment recommendation or a guarantee of benefit.

How can you prepare for a consultation?

Planning involves previous response, medication burden and hyperstimulation risk as well as egg yield. Review your previous protocol with Prof. Dr. Mehmet Çolakoğlu to clarify questions about a future cycle.

What does this research mean for your situation?

Let us begin with your diagnosis, previous findings and goals as a couple. You can request an initial consultation with Prof. Dr. Mehmet Çolakoğlu to discuss what this research means for your own situation.

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